Intrapatient variability in tacrolimus trough levels after solid organ transplantation varies at different postoperative time periods
نویسندگان
چکیده
منابع مشابه
Generic tacrolimus in solid organ transplantation.
The availability of a wide range of immunosuppressive therapies has revolutionized the management of patients who have undergone solid organ transplantation (SOT). However, the cost of immunosuppressive drugs remains high. This situation has led to the development of generic equivalents, which are similar in quality, safety, and efficacy to their approved innovator drugs. There are data availab...
متن کاملTacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation.
Tacrolimus (TAC) is an immunosuppressant drug discovered in 1984 by Fujisawa Pharmaceutical Co., Ltd. This drug belongs to the group of calcineurin inhibitors, which has been proven highly effective in preventing acute rejection after transplantation of solid organs. However, neurotoxicity and nephrotoxicity are its major adverse effects. Posterior reversible encephalopathy syndrome (PRES) is t...
متن کاملComparing Azole Plasma Trough Levels in Lung Transplant Recipients: Percentage of Therapeutic Levels and Intrapatient Variability
BACKGROUND This study compared therapeutic azole plasma trough levels (APL) of the azole antimycotics itraconazole (ITR), voriconazole (VOR), and posaconazole (POS) in lung transplant recipients and analyzed the influencing factors. In addition, intra-patient variability for each azole was determined. METHODS From July 2012 to July 2015, 806 APL of ITR, VOR, POS liquid (POS-Liq), and POS tabl...
متن کاملPregnancy after Solid Organ Transplantation.
PURPOSE To explore the reproductive decision-making process with women who were organ transplant recipients (renal, lung, & heart transplants). STUDY DESIGN AND METHODS Grounded theory guided data collection and analyses. Mixed methods with audiotaped telephone interviews and a written survey measuring social support were used. As social support is critical for women who are organ transplant ...
متن کاملInfluence of tacrolimus metabolism rate on renal function after solid organ transplantation
The calcineurin inhibitor (CNI) tacrolimus (TAC) is an integral part of the immunosuppressive regimen after solid organ transplantation. Although TAC is very effective in prevention of acute rejection episodes, its highly variable pharmacokinetic and narrow therapeutic window require frequent monitoring of drug levels and dose adjustments. TAC can cause CNI nephrotoxicity even at low blood trou...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2018
ISSN: 1600-6135
DOI: 10.1111/ajt.15134